| Autor: |
Naoya Nishioka, Tadaaki Yamada, Sachi Harita, Soichi Hirai, Yuki Katayama, Takayuki Nakano, Naoko Okura, Nobuyo Tamiya, Yoshiko Kaneko, Junji Uchino, Koichi Takayama |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Respiratory Medicine Case Reports, Vol 25, Iss , Pp 261-263 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0071 |
| DOI: |
10.1016/j.rmcr.2018.10.004 |
| Popis: |
NSCLC patients with EGFR mutations respond to EGFR-TKIs; however, the management of refractory tumors to EGFR-TKIs remains unclear. We demonstrated that repeated genetic testing might be useful for detecting resistance mechanisms as well as for decision-making in EGFR mutated NSCLC patients, following the emergence of resistance to the initial EGFR-TKIs.A 69-year-old man was diagnosed with lung adenocarcinoma with an EGFR exon 19 deletion. After tumor re-growth treated with erlotinib and chemotherapy, he was diagnosed with an SCLC transformation and administered chemotherapy to treat the SCLC. After the resistance of chemotherapy, the EGFR-T790M mutation by liquid biopsy was detected and treated him with osimertinib, which resulted in a clinical response. Keywords: Repeated genetic testing, Drug resistance, EGFR-T790M, SCLC transformation, Liquid biopsy |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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