| Autor: |
Hongye Wang, Dongshan Yan, Ya Li, Yanfei Gong, Yulin Mai, Bingxiang Li, Xiaoyong Zhu, Xinrui Wan, Liyun Xie, HuaKe Jiang, Min Zhang, Ming Sun, Yufeng Yao, Yongzhang Zhu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Infectious Diseases of Poverty, Vol 11, Iss 1, Pp 1-15 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2049-9957 |
| DOI: |
10.1186/s40249-022-00940-w |
| Popis: |
Abstract Background COVID-19 pandemic continues, clarifying signatures in clinical characters and antibody responses between severe and non-severe COVID-19 cases would benefit the prognosis and treatment. Methods In this study, 119 serum samples from 37 severe or non-severe COVID-19 patients from the First People's Hospital of Yueyang were collected between January 25 and February 18 2020. The clinical features, antibody responses targeting SARS-CoV-2 spike protein (S) and its different domains, SARS-CoV-2-specific Ig isotypes, IgG subclasses, ACE2 competitive antibodies, binding titers with FcγIIa and FcγIIb receptors, and 14 cytokines were comprehensively investigated. The differences between severe and non-severe groups were analyzed using Mann–Whitney U test or Fisher’s exact test. Results Severe group including 9 patients represented lower lymphocyte count, higher neutrophil count, higher level of LDH, total bile acid (TBA) (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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