Molecular evolution of enzymes involved in the arachidonic acid cascade

Autor: Hiroyuki Toh, Yoshihiro Urade, Tadashi Tanabe
Jazyk: angličtina
Rok vydání: 1992
Předmět:
Zdroj: Mediators of Inflammation, Vol 1, Iss 4, Pp 223-233 (1992)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
09629351
DOI: 10.1155/S0962935192000346
Popis: The metabolic pathway called the arachidonic acid cascade produces a wide range of eicosanoids, such as prostaglandins, thromboxanes and leukotrienes with potent biological activities. Recombinant DNA techniques have made it possible to determine the nucleotide sequences of cDNAs and/or genomic structures for the enzymes involved in the pathway. Sequence comparison analyses of the accumulated sequence data have brought great insights into the structure, function and molecular evolution of the enzymes. This paper reviews the sequence comparison analyses of the enzymes involved in the arachidonic acid cascade.
Databáze: Directory of Open Access Journals
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