| Autor: |
Miranda L. Curtiss, Alexander F. Rosenberg, Christopher D. Scharer, Betty Mousseau, Natalia A. Ballesteros Benavides, John E. Bradley, Beatriz León, Chad Steele, Troy D. Randall, Frances E. Lund |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2023.1158493 |
| Popis: |
IntroductionData from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.MethodsTo address whether Chi3l1 also contributes to TH2 responses following nematode infection, we infected Chi3l1-/- mice with Heligmosomoides polygyrus (Hp) and analyzed T cell responses.ResultsAs anticipated, we observed impaired TH2 responses in Hp-infected Chi3l1-/- mice. However, we also found that T cell intrinsic expression of Chi3l1 was required for ICOS upregulation following activation of naïve CD4 T cells and was necessary for the development of the IL-4+ TFH subset, which supports germinal center B cell reactions and IgE responses. We also observed roles for Chi3l1 in TFH, germinal center B cell, and IgE responses to alum-adjuvanted vaccination. While Chi3l1 was critical for IgE humoral responses it was not required for vaccine or infection-induced IgG1 responses.DiscussionThese results suggest that Chi3l1 modulates IgE responses, which are known to be highly dependent on IL-4-producing TFH cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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