| Autor: |
Simon Johannes Gairing, Sven Danneberg, Leonard Kaps, Michael Nagel, Eva Maria Schleicher, Charlotte Quack, Sinah Engel, Stefan Bittner, Peter Robert Galle, Jörn Markus Schattenberg, Marcus-Alexander Wörns, Felix Luessi, Jens Uwe Marquardt, Christian Labenz |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
JHEP Reports, Vol 5, Iss 4, Pp 100671- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-5559 |
| DOI: |
10.1016/j.jhepr.2023.100671 |
| Popis: |
Background & Aims: Blood biomarkers facilitating the diagnosis of covert hepatic encephalopathy (CHE) in patients with cirrhosis are lacking. Astrocyte swelling is a major component of hepatic encephalopathy. Thus, we hypothesised that glial fibrillary acidic protein (GFAP), the major intermediate filament of astrocytes, might facilitate early diagnosis and management. This study aimed to investigate the utility of serum GFAP (sGFAP) levels as a biomarker of CHE. Methods: In this bicentric study, 135 patients with cirrhosis, 21 patients with ongoing harmful alcohol use and cirrhosis, and 15 healthy controls were recruited. CHE was diagnosed using psychometric hepatic encephalopathy score. sGFAP levels were measured using a highly sensitive single-molecule array (SiMoA) immunoassay. Results: In total, 50 (37%) people presented with CHE at study inclusion. Participants with CHE displayed significantly higher sGFAP levels than those without CHE (median sGFAP, 163 pg/ml [IQR 136; 268] vs. 106 pg/ml [IQR 75; 153]; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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