Hepatitis B Viral Protein HBx: Roles in Viral Replication and Hepatocarcinogenesis

Autor:	Dong Li, Yassir Hamadalnil, Thomas Tu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	hepadnavirus HBV DNA integration cccDNA DBB1 hepatocellular carcinoma HCC Microbiology QR1-502
Zdroj:	Viruses, Vol 16, Iss 9, p 1361 (2024)
Druh dokumentu:	article
ISSN:	16091361 1999-4915
DOI:	10.3390/v16091361
Popis:	Hepatitis B virus (HBV) infection remains a major public health concern worldwide, with approximately 296 million individuals chronically infected. The HBV-encoded X protein (HBx) is a regulatory protein of 17 kDa, reportedly responsible for a broad range of functions, including viral replication and oncogenic processes. In this review, we summarize the state of knowledge on the mechanisms underlying HBx functions in viral replication, the antiviral effect of therapeutics directed against HBx, and the role of HBx in liver cancer development (including a hypothetical model of hepatocarcinogenesis). We conclude by highlighting major unanswered questions in the field and the implications of their answers.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/dd6fedcebb074966b795176281566fa4 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.