Early Postischemic Cerebral Circulatory Disorders and Their Correction with Perftoran
| Autor: | V. V. Aleksandrin, V. L. Kozhura, I. S. Novoderzhkina, V. V. Moroz |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Общая реаниматология, Vol 2, Iss 3, Pp 12-17 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1813-9779 2411-7110 |
| DOI: | 10.15360/1813-9779-2006-3-12-17 |
| Popis: | Objective: to study the conditions and mechanism of postischemic no-reflow and delayed hypoperfusion and to correct them with perfluorane.Materials and methods: Both phenomena were reproduced by using a rat model of global cerebral ischemia.Results: no-reflow was shown to be caused by pial arteriolar collapse that occurred in ischemia and lasted during reperfusion. Delayed postischemic hypoperfusion was induced by increased pial arteriolar tone.Conclusion: Intraarterial injection of perfluorane alleviates the manifestation of both phenomena due to better oxygen supply to ischemic brain tissue and, probably, to calcium channel blockage. |
| Databáze: | Directory of Open Access Journals |
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