Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation

Autor:	Ewa A. Grzybowska, Maciej Wakula
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	RNA-binding proteins coding sequence mammalian post-transcriptional gene expression Cytology QH573-671
Zdroj:	Cells, Vol 10, Iss 11, p 2910 (2021)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells10112910
Popis:	Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the functions thereof are more obscure. As described in this review, CDS binding has a role in the regulation of mRNA stability, but it has also a more intriguing role in the regulation of translational efficiency. Global approaches, which suggest the significance of CDS binding along with specific examples of CDS-binding RBPs and their modes of action, are outlined here, pointing to the existence of a relatively less-known regulatory network controlling mRNA stability and translation on yet another level.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6feae23f8c894cd4880f33a68e10b65e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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