Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines
Autor: | Sheng-Han Huang, Wan-Yu Huang, Guo-Lun Zhang, Te-Fang Yang |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Molecules, Vol 26, Iss 20, p 6126 (2021) |
Druh dokumentu: | article |
ISSN: | 1420-3049 45349665 |
DOI: | 10.3390/molecules26206126 |
Popis: | It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,β-unsaturated esters (18) and -unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out under appropriate conditions to provide the corresponding thiazolo[2,3-α]isoquinoline derivatives with good yields (up to 87%) and significant diastereomeric selectivity. The mechanism of the crucial reaction was discussed. |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |