| Autor: |
Joakim Håkansson, Lovisa Ringstad, Anita Umerska, Jenny Johansson, Therese Andersson, Lukas Boge, René T. Rozenbaum, Prashant K. Sharma, Petter Tollbäck, Camilla Björn, Patrick Saulnier, Margit Mahlapuu |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2235-2988 |
| DOI: |
10.3389/fcimb.2019.00174 |
| Popis: |
Antimicrobial peptides, also known as host defense peptides, have recently emerged as a promising new category of therapeutic agents for the treatment of infectious diseases. This study evaluated the preclinical in vitro, ex vivo, and in vivo antimicrobial activity, as well as the potential to cause skin irritation, of human kininogen-derived antimicrobial peptide DPK-060 in different formulations designed for topical delivery. We found that DPK-060 formulated in acetate buffer or poloxamer gel caused a marked reduction of bacterial counts of Staphylococcus aureus in vitro (minimum microbicidal concentration |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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