Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice

Autor: Anthony Martin, Gertrude Ecklu-Mensah, Connie W. Y. Ha, Gustaf Hendrick, Donald K. Layman, Jack Gilbert, Suzanne Devkota
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-24074-z
Popis: Dietary protein restriction induces a hepatic stress response mediated by the endocrine molecule FGF21, which triggers host adaptive pathways. Here the authors demonstrate that the gut microbiome is required to trigger the FGF21 response and can be manipulated through dietary fiber supplementation.
Databáze: Directory of Open Access Journals