Reactivation of Pulmonary Tuberculosis following Treatment of Myelofibrosis with Ruxolitinib

Autor:	Maheen Z. Abidi, Javeria Haque, Parvathi Varma, Horatiu Olteanu, Guru Subramanian Guru Murthy, Binod Dhakal, Parameswaran Hari
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Case Reports in Hematology, Vol 2016 (2016)
Druh dokumentu:	article
ISSN:	2090-6560 2090-6579
DOI:	10.1155/2016/2389038
Popis:	Ruxolitinib is widely in use for treatment of myeloproliferative disorders. It causes inhibition of the Janus kinase (JAK) signal transducer and activation of transcription (STAT) pathway, which plays a key role in the underlying pathophysiology of myeloproliferative diseases. We describe a case of reactivation pulmonary tuberculosis in a retired physician while on treatment with ruxolitinib. We also review the literature on opportunistic infections following use of ruxolitinib. Our case highlights the importance of screening for latent tuberculosis in patients from highly endemic areas prior to start of therapy with ruxolitinib.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6fb9c122b64943bc99d3321fc7447a57 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF