The Synergic Effects of Atorvastatin (0/1m) and (10 m) and Extremely Low Frequency Electromagnetic Field on Angiogenesis

Autor: Javad Baharara, Saeideh Zafar-Balanezhad, Khadijeh Nejad Shahrokh Abadi, Zahra Hesami
Jazyk: perština
Rok vydání: 2012
Předmět:
Zdroj: مجله دانشگاه علوم پزشکی بیرجند, Vol 19, Iss 2, Pp 148-156 (2012)
Druh dokumentu: article
ISSN: 1607-2197
2423-6152
Popis: Background and aim: statins promote the proliferation and survival of endothelial cells. Angiogenesis is the formation of new blood vessels from pre-existing ones.It contributes to physiological and pathophysiological condition. In this research we used atorvastatin (0/1m) and (10m) with electromagnetic field on angiogenesis of chick embryo. Method: in this experiment study 98 Ross fertilized eggs were randomly divided in to 7 groups as: following:control group,1)group sham-exposed,2) group treated with atorvastatin (0/1 m), 3)group treated with atorvastatin (10m),4) group treated with electromagnetic field,5) group treated with both atorvastatin (0/1m) and electromagnetic field,6) group treated with both atorvastatin (10m) and electromagnetic field. In day2, a window was opened on eggs in sterile condition in days 8a gelatin sponge was placed on chorioalantoic membrane(CAM) and was soaked with 10l atorvastatin (0/1 m) and (10m) in groups (3,6) and groups (2 , 5) and groups (4,5,6) were placed in 50 Gauss magnetic field for 4 hours in day 10.In day 12,CAMs were examined and photographed by research photo-stereo microscope in all case. Data were analyzed statistically by t-test and ANOVA(P0/05).comparison between average number and length of vessels in control and group 2 and groups 3, 6 a significant increase and decrease was shown in the average number and length of vessels compared with control(p
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