| Autor: |
Iosief Abraha, Paolo Eusebi, Marta Micheli, Antonella Germani, Erica Pasquarelli, Sofia Pascolini, Rossana Antonietti, Sandro Argenti, Alessandra Fioravanti, Elisa Martini, Luana Aristei, Paola Mancinelli, Maria Letizia Ottaviani, Martina Roselli, Milena Barzacca, Erika Belardinelli |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 12, Iss 7 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2021-056370 |
| Popis: |
Objectives Dynamics of antibody responses following SARS-CoV-2 infection are controversial in terms of immunity and persistence. We aimed to assess longitudinally the trend of antibody serological titres, their correlation with clinical severity as well as clinical reinfection during a follow-up.Design Longitudinal cohort, 12 months follow-up study.Setting USL Umbria 2.Participants Consecutive subjects aged 15–75 who were discharged with the diagnosis of Sars-Cov-2 from the hospitals of the AUSL Umbria 2, or resulted positive to a PCR test for SARS-CoV-2 infection with or without symptoms were recruited. SARS-CoV-2 serological testing for antibodies targeting the Nucleocapside and Spike proteins were determined.Results Of 184 eligible subjects, 149 were available for evaluation: 17 were classified as oligo/asymptomatic, 107 as symptomatic, 25 as hospital admitted. Participants differed in terms of signs and symptoms as well as treatment. Overall there was a significant difference in terms of antibody titres between groups (anti-S: p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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