| Autor: |
Shazli Azmi, Maryam Ferdousi, Yifen Liu, Safwaan Adam, Tarza Siahmansur, Georgios Ponirakis, Andrew Marshall, Ioannis N. Petropoulos, Jan Hoong Ho, Akheel A. Syed, John M. Gibson, Basil J. Ammori, Paul N. Durrington, Rayaz A. Malik, Handrean Soran |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-90346-9 |
| Popis: |
Abstract Obesity and associated dyslipidemia may contribute to increased cardiovascular disease. Obesity has also been associated with neuropathy. We have investigated presence of peripheral nerve damage in patients with severe obesity without type 2 diabetes and the status of metabolic syndrome and lipoprotein abnormalities. 47participants with severe obesity and 30 age-matched healthy controls underwent detailed phenotyping of neuropathy and an assessment of lipoproteins and HDL-functionality. Participants with severe obesity had a higher neuropathy symptom profile, lower sural and peroneal nerve amplitudes, abnormal thermal thresholds, heart rate variability with deep breathing and corneal nerve parameters compared to healthy controls. Circulating apolipoprotein A1 (P = 0.009), HDL cholesterol (HDL-C) (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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