Concentration Sensitivity of Nucleic Acid and Protein Molecule Detection Using Nanowire Biosensors

Autor: Yuri D. Ivanov, Vadim Yu. Tatur, Alexander V. Glukhov, Vadim S. Ziborov
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biophysica, Vol 1, Iss 3, Pp 328-333 (2021)
Druh dokumentu: article
ISSN: 2673-4125
DOI: 10.3390/biophysica1030024
Popis: The concentration detection limit (DL) of biomacromolecules attainable using a nanowire detector has become a topical issue. A DL of 10−15 M is required to reveal oncological and infectious diseases at an early stage. This study discusses the DL experimentally attainable in the subfemtomolar concentration range, and possible mechanisms explaining such a low-concentration DL through the cooperative effect of biomacromolecular complexes formed on the surface of the nanowire (NW) chip near the nanowire.
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