Virologic and immunologic effectiveness of darunavir-based salvage therapy in HIV-1-infected adults in a Brazilian clinical practice setting: results of a multicenter and retrospective cohort study

Autor: Karina Mota Ribeiro, Fernando Martin Biscione, Mateus Rodrigues Westin, Danielle Pessoa Machado, Dirceu Bartolomeu Greco, Unaí Tupinambás
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Brazilian Journal of Infectious Diseases, Vol 18, Iss 1, Pp 1-7 (2014)
Druh dokumentu: article
ISSN: 1413-8670
DOI: 10.1016/j.bjid.2013.04.001
Popis: Background: Darunavir has been proven efficacious for antiretroviral-experienced HIV-1-infected patients in randomized trials. However, effectiveness of darunavir-based salvage therapy is understudied in routine care in Brazil. Methods: Retrospective cohort study of HIV-1-infected patients from three public referral centers in Belo Horizonte, who received a darunavir-based therapy between 2008 and 2010, after virologic failure. Primary endpoint was the proportion of patients with viral load
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