Prediagnostic Smoking and Alcohol Drinking and Gastric Cancer Survival: A Korean Prospective Cohort Study

Autor: Shin Ah Kim, Bo Youl Choi, Kyu Sang Song, Chan Hyuk Park, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Hyun Ja Kim
Jazyk: English<br />Korean
Rok vydání: 2019
Předmět:
Zdroj: The Korean Journal of Gastroenterology, Vol 73, Iss 3, Pp 141-151 (2019)
Druh dokumentu: article
ISSN: 1598-9992
DOI: 10.4166/kjg.2019.73.3.141
Popis: Background : /Aims: Behavioral factors, such as smoking and heavy alcohol consumption, increase the risk of gastric cancer (GC), but their effects on survival are not clear. We examined associations between prediagnostic smoking and alcohol drinking behavior and GC death by long-term follow-up. Methods : : The participants were 508 GC patients enrolled at Chungnam University Hospital and Hanyang University Guri Hospital from 2001 to 2006. Information on clinicopathologic and behavioral risk factors was collected, and patient survival was prospectively followed until 2016 by medical chart review and telephone survey. Results : : During above 10 years follow-up period, overall death was 46.2% (n=226) and GC deaths was 38.2% (n=187) among the 489 GC patients included in the analysis. No significant association was found between smoking habits and overall or GC survival. However, after stratification by histological type, the hazard ratio (HR) of GC death for current smokers tended to be higher for the diffuse type (HR 1.61, 95% CI 0.57-4.59 for current vs. never) rather than for the intestinal type (HR 0.78, 95% CI 0.28-2.19 for current vs. never). Light alcohol consumption was found to be associated with a significantly lower risk of GC death (HR 0.52, 95% CI 0.36-0.75 for
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