Aspects of DryLab® software application in chromatography methods optimization and robustness testing
| Autor: | Terzić Jelena, Popović Igor, Jančić-Stojanović Biljana |
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| Jazyk: | srbština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Arhiv za farmaciju, Vol 64, Iss 3, Pp 205-219 (2014) |
| Druh dokumentu: | article |
| ISSN: | 0004-1963 2217-8767 |
| DOI: | 10.5937/arhfarm1403205T |
| Popis: | In this review article, aspects of DryLab® software application in liquid chromatography are given. Literature survey shows wide application of software for chromatography method development, optimization, as well as for robustness testing. Earlier versions of DryLab®software enabled the simultaneous monitoring of the impact of two parameters on the selected system response, as an upgraded version of the software provides significantly more opportunities. Namely, the new DryLab®software version enables fulfilling requirements given by Quality by Design (QbD) concept through a systematic approach to the development of chromatographic methods, and the construction of a 3D cube which provides the visualization of a Design Space. In addition, when running liquid chromatography methods on a routine basis software can be a useful tool for optimization process in order to minimize retention times and run time, as well as facilitating the transfer of a method (DryLab® data can be sent electronically). Finally, DryLab®software provides useful information about the method and can be applied to training of young analysts without performing experiments, while saving time, money, and laboratory instruments. |
| Databáze: | Directory of Open Access Journals |
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