| Autor: |
Hanene Jrah-Harzallah, Sonia Ben-Hadj-Khalifa, Aya Maloul, Rabeb El-Ghali, Touhami Mahjoub |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 5, Iss 3, Pp 1310-1316 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2013.04.017 |
| Popis: |
The effect of thymoquinone (TQ), the abundant component of black cumin seed (Nigella sativa) oil extract, was evaluated on 1,2-dimethylhydrazine (DMH)-induced erythrocyte oxidative stress and haematological perturbations during colon cancer promotion in rats. Two TQ approaches, the pre- and post-treatment, were used. DMH promoted erythrocyte oxidative damage in rats by enhancing lipid peroxidation (30%) and decreasing antioxidant enzymes activities (20–35%). This was associated with the decline of erythrocyte count, haemoglobin concentration and haematocrit (20%) and the count increase of white blood cell (60%) and platelet (180%). TQ pre-treatment repaired DMH-induced erythrocyte oxidative stress, anaemia, leukocytosis, and thrombocytosis and allowed a 60% of tumour incidence decline. TQ post-treatment exerted a slight effect on erythrocyte oxidative stress and reduced colon cancer incidence by 30% only. Thus, TQ efficacy in preventing DMH-induced colon cancer promotion was related to its virtue antioxidant effect on erythrocyte oxidative stress. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect