Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life

Autor:	R. A. Hutchinson, K. L. Costeloe, W. G. Wade, M. R. Millar, K. Ansbro, F. Stacey, P. F. Fleming
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Gut Pathogens, Vol 15, Iss 1, Pp 1-13 (2023)
Druh dokumentu:	article
ISSN:	1757-4749
DOI:	10.1186/s13099-023-00544-1
Popis:	Abstract Background Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis in preterm babies. However, the effect of modulators of bacterial growth (e.g. antibiotics) upon the developing microbiome is not well-characterised. In this prospectively-recruited, retrospectively-classified, case–control study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess the within-subject relationship between antibiotic administration and microbiome development, in comparison to preterm infants with minimal antibiotic exposure. Results During courses of antibiotics, diversity progression fell in comparison to that seen outside periods of antibiotic use (-0.71units/week vs. + 0.63units/week, p
Databáze:	Directory of Open Access Journals
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