Enantiocomplementary Bioreduction of 1-(Arylsulfanyl)propan-2-ones

Autor:	Emese Sándor, Pál Csuka, László Poppe, József Nagy
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	ketoreductase whole-cell bioreduction yeast thiophenol derivatives alcohol dehydrogenase Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 16, p 3858 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29163858
Popis:	This study explored the enantiocomplementary bioreduction of substituted 1-(arylsulfanyl)propan-2-ones in batch mode using four wild-type yeast strains and two different recombinant alcohol dehydrogenases from Lactobacillus kefir and Rhodococcus aetherivorans. The selected yeast strains and recombinant alcohol dehydrogenases as whole-cell biocatalysts resulted in the corresponding 1-(arylsulfanyl)propan-2-ols with moderate to excellent conversions (60–99%) and high selectivities (ee > 95%). The best bioreductions—in terms of conversion (>90%) and enantiomeric excess (>99% ee)—at preparative scale resulted in the expected chiral alcohols with similar conversion and selectivity to the screening reactions.
Databáze:	Directory of Open Access Journals
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