Pathophysiology of chronic peripheral ischemia: new perspectives
| Autor: | Salvatore Santo Signorelli, Luca Vanella, Nader G. Abraham, Salvatore Scuto, Elisa Marino, Petra Rocic |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Chronic Disease, Vol 11 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2040-6231 20406223 |
| DOI: | 10.1177/2040622319894466 |
| Popis: | Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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