Antihyperalgesic effect of exercise is augmented by the oral pretreatment with extract of in an animal model of osteoarthritis
| Autor: | Shayany Dalbem Pascoalino, Daniela Dero Lüdtke, Ana Caroline Heymanns, Daiana Salm, Déborah M Costa, Daniel Fernandes Martins, Verônica V Horewicz, Franciane Bobinski, Anna Paula Piovezan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Orthopaedics, Trauma and Rehabilitation, Vol 27 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2210-4917 2210-4925 22104917 |
| DOI: | 10.1177/2210491720935614 |
| Popis: | Background/Purpose: Osteoarthritis (OA) is the main orthopedic disease to cause pain and edema in humans. This study evaluated the influence of complementary medicine on the hyperalgesia and edema induced by exercise in an animal model of OA as well as possible role for interleukin (IL)-1β to these outcomes. Methods: Mice (25–35 g) were subjected to intraplantar injection of Freund’s complete adjuvant and were subjected to exercise and oral treatment with ethanolic crude extract of Casearia sylvestris (ECE-CS) or vehicle (alone or in combination) and evaluated through behavioral and biochemical tests. Results: At day 5, exercise and ECE-CS alone did not reduce hyperalgesia, while the combination of both enhanced this effect. In muscle and skin tissues from the treated paw of mice, both treatments alone or in combination reduced in similar extent the levels of IL-1β in relation to the control group. Conclusion: Association of both complementary therapies may bring benefits on pain associated with OA in humans. |
| Databáze: | Directory of Open Access Journals |
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