Th1Th17CM Lymphocyte Subpopulation as a Predictive Biomarker of Disease Activity in Multiple Sclerosis Patients under Dimethyl Fumarate or Fingolimod Treatment

Autor: Bibiana Quirant-Sánchez, Silvia Presas-Rodriguez, María José Mansilla, Aina Teniente-Serra, José V. Hervás-García, Luis Brieva, Ester Moral-Torres, Antonio Cano, Elvira Munteis, Juan Navarro-Barriuso, Eva M. Martínez-Cáceres, Cristina Ramo-Tello
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Mediators of Inflammation, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
DOI: 10.1155/2019/8147803
Popis: Peripheral blood biomarkers able to predict disease activity in multiple sclerosis (MS) patients have not been identified yet. Here, we analyzed the immune phenotype of T lymphocyte subpopulations in peripheral blood samples from 66 RRMS patients under DMF (n=22) or fingolimod (n=44) treatment, by flow cytometry. A correlation study between the percentage and absolute cell number of each lymphocyte subpopulation with the presence of relapses or new MRI lesions during 12-month follow-up was performed. Patients who had undergone relapses showed at baseline higher percentage of Th1CM cells (relapsed: 11.60±4.17%vs. nonrelapsed: 9.25±3.17%, p11.48% had a 50% relapse-free survival compared to patients with Th1Th17CMcells
Databáze: Directory of Open Access Journals
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