| Autor: |
Antonios Papadopoulos, Nikolaos Tziolos, Aristine Cheng, Georgios Tsioulos, Konstantinos Thomas, Christina Kotsogianni, Agellos Banos, Julie E. Niemela, Tom DiMaggio, Steven Holland, Sergio D. Rosenzweig, Michail S. Lionakis, Dimitrios T. Boumpas |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
RMD Open, Vol 9, Iss 2 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2056-5933 |
| DOI: |
10.1136/rmdopen-2023-003149 |
| Popis: |
Infections are among the most serious complications in patients with systemic lupus erythematosus (SLE), with bacterial and viral infections being the most common. Non-tuberculous mycobacterial (NTM) infections are quite rare and are typically seen in older patients with SLE with longstanding disease duration treated with corticosteroids. Here, we describe a 39-year-old woman with SLE and an unusual pattern of recurrent NTM disseminated infections. After excluding the presence of autoantibodies against interferon-γ, whole exome sequencing revealed a homozygous polymorphism in the NF-kappa-B essential modulator (NEMO) gene. Primary immunodeficiencies should be included in the differential diagnosis of patients with recurrent opportunistic infections, even in those with iatrogenic immunosuppression. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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