| Autor: |
Juliana Giacomazzi, Patricia Klarmann Ziegelmann, Samanta da Costa, Camila Matzenbacher Bittar, Fernando Mariano Obst, Clévia Rosset, Gabriel S. Macedo, Hugo Bock, Thais Canal, Mari Ines Paese, Jean Lucas Benvenuti, Maria Carolina Buj, Patricia Ashton-Prolla, José Roberto Goldim, Roberta Pozza |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
JCO Global Oncology, Vol , Iss 9 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2687-8941 |
| DOI: |
10.1200/GO.23.00006 |
| Popis: |
PURPOSETo evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years and to characterize them for hereditary cancer syndrome (HCS) phenotypes.METHODSA case-control (matched by age group and sex) study was conducted on regional cancer. Data on exposure factors and first-/second-degree family history of cancer (1/2FHC) were collected. The MGPT was performed using Illumina next-generation sequencing technology.RESULTSA total of 1,007 cases and 1,007 controls were included. The most frequent cancers were BC (n = 311), CCR (n = 147), prostate (n = 132), and lung cancers (n = 89). It was independently associated with cancer, 1/2FHC, tobacco consumption (TC), pesticide exposure (PE), solvent/glue exposure, and BMI |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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