| Popis: |
Aim: In the present study we aimed to check the impact of maximal androgen deprivation therapy (MADT) on cellular blood components such as hemoglobin (Hb) and hematocrit (Htc) fasting blood glucose (FBG), serum lipid values and bone mineral density (BMD) in locally advanced prostate cancer.Patients and Methods: Having been treated with maximal androgen blockade therapy, thirty-nine patients' initial values and at the twelfth month values of hemoglobin (Hb), hematocrit (Htc), FBG, total cholesterol (tChol), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and spine BMD were recorded. Statistical comparisons of initial and at the twelfth month values were performed. Results: A statistically significant decrease was recorded in Hb and BMD values after one year MADT. On the other hand, TG, tChol, LDL, HDL and FBG values showed a statistically significant increase. Although Hb levels were significantly reduced, none of our patients developed symptoms of anemia. Fourteen of 37 patients whose FBG levels were under 110 mg/dl before treatment, increased over 110 mg/dl at the twelfth month of treatment. Seven patients developed diabetes mellitus (DM) after treatment. Moreover, T score evaluation revealed newly developed osteoporosis in 4 patients. All of the patients with developed osteoporosis had osteopenic T score values before treatment. No bone fractures occurred in any of our patients. Conclusion: Our study points out the increase of FBG related to the treatment of MADT. Decrease in BMD is higher in previously osteopenic patients. The lack of bone fracture and anemia symptoms might be considered as a result of evaluation of the early data on MADT. |
