Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens

Autor:	David Lund, Roelof Dirk Coertze, Marcos Parras-Moltó, Fanny Berglund, Carl-Fredrik Flach, Anna Johnning, D. G. Joakim Larsson, Erik Kristiansson
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Biology (General) QH301-705.5
Zdroj:	Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Druh dokumentu:	article
ISSN:	2399-3642
DOI:	10.1038/s42003-023-05174-6
Popis:	Abstract Antibiotic resistance is a growing threat to human health, caused in part by pathogens accumulating antibiotic resistance genes (ARGs) through horizontal gene transfer. New ARGs are typically not recognized until they have become widely disseminated, which limits our ability to reduce their spread. In this study, we use large-scale computational screening of bacterial genomes to identify previously undiscovered mobile ARGs in pathogens. From ~1 million genomes, we predict 1,071,815 genes encoding 34,053 unique aminoglycoside-modifying enzymes (AMEs). These cluster into 7,612 families (
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6eb32acca2124b25aaccb5045f9f3ad2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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