| Autor: |
Delyana M. Davcheva, Gergana K. Kirova, MariaMaria Zh. Miteva, Todorka Z. Tzvetkova, Maria M. Orbetzova, Boyan I. Nonchev, Kiril K. Simitchiev, Veselin J. Kmetov |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Folia Medica, Vol 64, Iss 3, Pp 443-449 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1314-2143 |
| DOI: |
10.3897/folmed.64.e64997 |
| Popis: |
Abstract Introduction: Selenium (Se) is one of the environmental factors with an essential role in the pathogenesis of autoimmune thyroid disease (ATD). Scarce data is available for the selenium status of the Bulgarian population especially for patients with thyroid disorders. Aim: To compare the serum selenium (s-Se) concentrations in patients with ATD and healthy controls from Bulgarian population. Materials and methods: The s-Se concentrations were measured in 105 patients newly diagnosed or untreated for the previous 6 months with ATD (mean age 44±13 years). The patients were divided into three groups: euthyroid autoimmune thyroiditis (AIT) (n=31), hypothyroid AIT (n=33), and hyperthyroid patients with AIT or Graves’ disease (GD) (n=41). The results were compared to s-Se concentrations in 40 age- and sex-matched healthy controls. Determination of s-Se was carried out by inductively coupled plasma mass spectrometry (ICP-MS) after microwave-assisted acid mineralization of the serum samples. Results: The s-Se concentrations in patients with hyperthyroidism were significantly lower than those in the control group (hyperthyroidism: 69±15.0 µg/L vs. controls: 84±13 µg/L, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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