| Autor: |
Yoon-Tae Kang, Anusha Mutukuri, Thomas Hadlock, Heather Fairbairn, Taylor R. Carle, Shamileh Fouladdel, Vasudha Murlidhar, Aaron Kramer, Monica De Silva Reguera, Ebrahim Azizi, Alison Durham, Scott A. Mclean, Sunitha Nagrath |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Advanced NanoBiomed Research, Vol 2, Iss 8, Pp n/a-n/a (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2699-9307 |
| DOI: |
10.1002/anbr.202100083 |
| Popis: |
Melanoma is one of the most aggressive skin cancers due to its potential to metastasize widely in the body. The risk of metastasis is increased with later detection and increased thickness of the primary lesion, thus early identification/surgical removal is critical for higher survival rates. Recent advances in liquid biopsy have proposed less‐invasive alternatives for cancer diagnosis and monitoring using minimal invasion at sample collection, and circulating tumor cells (CTCs) have been considered a promising blood‐based surrogate marker of primary tumors. Herein, the melanoma‐specific OncoBean platform (MelanoBean) conjugated with melanoma specific antibodies is used. From the comprehensive studies based on change in the number and characteristics of CTCs/CTCs‐clusters pre‐ and post‐surgical treatment, this work demonstrates that melanoma patients (n = 45) at all stages (I–IV) have a noticeable number of CTCs as well as CTC‐clusters compared to healthy donors (n = 9) (p = 0.0011), and surgical treatment leads to a significant decrease in the CTC number (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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