Host Transcription Factors in Hepatitis B Virus RNA Synthesis

Autor:	Kristi L. Turton, Vanessa Meier-Stephenson, Maulik D. Badmalia, Carla S. Coffin, Trushar R. Patel
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	hepatitis b virus (hbv) viral replication transcription factors covalently closed circular dna (cccdna) host–viral interactions Microbiology QR1-502
Zdroj:	Viruses, Vol 12, Iss 2, p 160 (2020)
Druh dokumentu:	article
ISSN:	1999-4915 41647440
DOI:	10.3390/v12020160
Popis:	The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein−HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors’ interactions with HBV cccDNA is discussed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e6eac2b416474400a26900fdf50f59bf Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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