| Autor: |
Wan-Hao Tsai, Yen-Chun Lin, Shih-Hsun Lan, Yu-Heng Lin, Chun-Hsiung Chen, Song-Chou Hsieh, Chin-Hsiu Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 80, Iss , Pp 103508- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2024.103508 |
| Popis: |
Human leukocyte antigen (HLA)-B27 is the genetic marker for ankylosing spondylitis (AS). Here, we generated induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells of a male AS patient carrying HLA-B27 with syndesmophyte formation by using the Sendai-virus delivery system. The resulting iPSCs had a normal karyotype, expressed pluripotent markers, and could differentiate into three germ layers. This cellular model will provide a platform for studying pathological mechanisms of new bone formation in HLA-B27 positive AS patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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