EWAS of post-COVID-19 patients shows methylation differences in the immune-response associated gene, IFI44L, three months after COVID-19 infection

Autor: Yunsung Lee, Espen Riskedal, Karl Trygve Kalleberg, Mette Istre, Andreas Lind, Fridtjof Lund-Johansen, Olaug Reiakvam, Arne V. L. Søraas, Jennifer R. Harris, John Arne Dahl, Cathrine L. Hadley, Astanand Jugessur
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2045-2322
22480994
DOI: 10.1038/s41598-022-15467-1
Popis: Abstract Although substantial progress has been made in managing COVID-19, it is still difficult to predict a patient’s prognosis. We explored the epigenetic signatures of COVID-19 in peripheral blood using data from an ongoing prospective observational study of COVID-19 called the Norwegian Corona Cohort Study. A series of EWASs were performed to compare the DNA methylation profiles between COVID-19 cases and controls three months post-infection. We also investigated differences associated with severity and long-COVID. Three CpGs—cg22399236, cg03607951, and cg09829636—were significantly hypomethylated (FDR
Databáze: Directory of Open Access Journals
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