Impact of childhood and maternal vaccination against diphtheria, tetanus, and pertussis in Colombia

Autor: María Cristina Hoyos, Doracelly Hincapié-Palacio, Jesus Ochoa, Alba León
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Public Health Research (2021)
Druh dokumentu: article
ISSN: 2279-9028
2279-9036
DOI: 10.4081/jphr.2021.2588
Popis: Background: In Latin America, there are few studies of the impact of vaccination against diphtheria, tetanus, and pertussis. We estimate the impact of infant and maternal vaccination on the incidence of these diseases in Colombia. Design and methods: an interrupted time series study analyzing the incidence before and after of vaccination with DwPT (1975-2018) and with Tdap in pregnant women (2008-2018). A segmented regression model with negative binomial distribution estimated the change in level and trend of the predicted incidence ratio after vaccination in relation to the incidence if vaccination had not been started (IRR), using a Prais Winsten regression. Results: The pertussis IRR decreased immediately after the start of childhood vaccination (0.91, p=0.51), but this was only significant (1.01, p
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