| Autor: |
Giulia Collatuzzo, Federica Teglia, Claudio Pelucchi, Eva Negri, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Lizbeth López-Carrillo, Nuno Lunet, Samantha Morais, Nuria Aragonés, Victor Moreno, Jesus Vioque, Manoli Garcia de la Hera, Mary H. Ward, Reza Malekzadeh, Mohammadreza Pakseresht, Raúl Ulises Hernández-Ramírez, Malaquias López-Cervantes, Rossella Bonzi, Michela Dalmartello, Shoichiro Tsugane, Akihisa Hidaka, M. Constanza Camargo, Maria Paula Curado, Zuo-Feng Zhang, Nadia Zubair, Carlo La Vecchia, Shailja Shah, Paolo Boffetta |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Nutrients, Vol 14, Iss 12, p 2555 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2072-6643 |
| DOI: |
10.3390/nu14122555 |
| Popis: |
Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83–0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77–0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81–0.94), and for diffuse (OR = 0.79, 95% CI = 0.69–0.89) and intestinal type (OR = 0.88, 95% CI = 0.79–0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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