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Faiz Bhora,1 Sudip K Ghosh,2 Edmund Kassis,3 Andrew Yoo,4 Sushama Ramisetti,4 Stephen S Johnston,4 Sadiq Rehmani,5 Iftekhar Kalsekar41Health Quest Health System, Poughkeepsie, NY 12601, USA; 2Global Health Economics and Market Access, Ethicon, Inc., Cincinnati, OH, USA; 3Medical Affairs, Ethicon, Inc., Cincinnati, OH, USA; 4Medical Devices - Epidemiology, Johnson and Johnson, New Brunswick, NJ, USA; 5Department of Thoracic Surgery, Mount Sinai St. Luke‘s Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USAPurpose: To assess whether tumor location during thoracic lobectomies affects economic outcomes or air leak complications.Patients and methods: Retrospective, observational study using Premier Healthcare Database. The study included patients aged ≥18 years who underwent elective inpatient thoracic lobectomy for lung cancer between 2012 and 2014 (first qualifying=index admission). Three mutually exclusive tumor location groups were formed: upper lobe, middle lobe, and lower lobe. Primary outcomes were index admission’s length of stay (LOS), total hospital costs, and operating room time; in-hospital air leak complications (composite of air leak/pneumothorax) served as an exploratory outcome. Multivariable models were used to examine the association between tumor location and the study outcomes, accounting for covariates and hospital-level clustering.Results: 8,750 thoracic lobectomies were identified: upper lobe (n=5,284), middle lobe (n=512), and lower lobe (n=2,954). Compared with the upper lobe, the middle and lower lobe groups had statistically significant (p |