A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene

Autor:	Nicolai A. Aksenov, Nikolai A. Arutiunov, Igor A. Kurenkov, Vladimir V. Malyuga, Dmitrii A. Aksenov, Daria S. Momotova, Anna M. Zatsepilina, Elizaveta A. Chukanova, Alexander V. Leontiev, Alexander V. Aksenov
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	C3-amination of indoles cascade transformations phenylacetonitrile extrusion Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 9, p 3657 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28093657
Popis:	A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4′-phenyl-4′H-spiro[indole-3,5′-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6e64230369434180b0f330b43580a3ac Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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