QSAR studies and antimicrobial potential of 1,3-thiazolylphosphonium salts
| Autor: | M. M. Trush, V. V. Kovalishyn, V. M. Blagodatnyi, V. S. Brovarets, S. G. Pilyo, V. M. Prokopenko, D. M. Hodyna, L. O. Metelytsia |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | The Ukrainian Biochemical Journal, Vol 88, Iss 4, Pp 57-65 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2409-4943 2413-5003 |
| DOI: | 10.15407/ubj88.04.057 |
| Popis: | The regression QSAR models were built to predict the antimicrobial activity of new thiazole derivatives. Compounds with high predicting activity were synthesized and evaluated against Gram-positive and Gram-negative bacteria and fungi. 1,3-Thiazole-4-ylphosphonium salts 4 and 5 displayed good antibacterial properties and high antifungal activity. The predictions are in a good agreement with the experiment results, which indicate the good predictive power of the created QSAR models. |
| Databáze: | Directory of Open Access Journals |
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