Axonal excitability and conduction alterations caused by levobupivacaine in rat
| Autor: | Tuncer Seçkin, Tuncer Peker Tülay, Burat İlksen, Kiziltan Erhan, İlhan Barkin, Dalkiliç Nizamettin |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Acta Pharmaceutica, Vol 67, Iss 3, Pp 293-307 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1846-9558 2017-0025 |
| DOI: | 10.1515/acph-2017-0025 |
| Popis: | In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction method over sciatic nerves of Wistar rats before and after administration of 0.05 % (1.7 mmol L−1) levobupivacaine. Levobupivacaine caused complete CNAP area and amplitude depression by blocking conduction in a time-dependent manner. |
| Databáze: | Directory of Open Access Journals |
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