Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal

Autor: Laura Oller, Kimberley A. Bennett, J. Chris McKnight, Simon E.W. Moss, Ryan Milne, Ailsa J. Hall, Joel Rocha
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 2051-817X
DOI: 10.14814/phy2.14972
Popis: Abstract Excessive adiposity is associated with altered oxygen tension and comorbidities in humans. In contrast, marine mammals have high adiposity with no apparent detrimental effects. However, partial pressure of oxygen (Po2) in their subcutaneous adipose tissue (blubber) and its relationship with fatness have not been reported. We measured Po2 and temperature at different blubber depths in 12 healthy juvenile grey seals. Fatness was estimated from blubber thickness and morphometric parameters. Simultaneously, we monitored breathing pattern; heart rate and arterial blood saturation with a pulse oximeter; and relative changes in total hemoglobin, deoxyhemoglobin, and oxyhemoglobin in blubber capillaries using near‐infrared spectroscopy (NIRS) as proxies for local oxygenation changes. Blubber Po2 ranged from 14.5 to 71.4 mmHg (39.2 ± 14.1 mmHg), which is similar to values reported in other species. Blubber Po2 was strongly and negatively associated with fatness (LME: p
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje