Three-dimensional structure determination of protein complexes using matrix-landing mass spectrometry

Autor: Michael S. Westphall, Kenneth W. Lee, Austin Z. Salome, Jean M. Lodge, Timothy Grant, Joshua J. Coon
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-29964-4
Popis: Mass spectrometry (MS) is a powerful tool for the structural characterization of protein complexes. Here the authors offer a path for direct integration of MS and electron microscopy with a MS approach that enables grid deposition and structural preservation of gaseous protein complex ions.
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