Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis

Autor:	Feifei Yan, Shoumeng Yan, Jing Wang, Yani Cui, Feinan Chen, Fang Fang, Weiwei Cui
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Triglyceride glucose index Cerebrovascular disease Observational research meta‒analysis Dose‒response relationship Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-16 (2022)
Druh dokumentu:	article
ISSN:	1475-2840
DOI:	10.1186/s12933-022-01664-9
Popis:	Abstract Background The triglyceride glucose (TyG) index, which is a new surrogate indicator of insulin resistance (IR), is thought to be associated with many diseases, such as cardiovascular disease, but its relationship with cerebrovascular disease is still controversial. Methods The PubMed, EMBASE, Cochrane Library, Web of Science and Medline databases were searched until March 2022 to evaluate the association between the TyG index and cerebrovascular disease risk. A random‒effects model was used to calculate the effect estimates and 95% confidence intervals (CIs). Results A total of 19 cohort studies and 10 case‒control/cross‒sectional studies were included in our study, which included 11,944,688 participants. Compared with a low TyG index, a higher TyG index increased the risk of cerebrovascular disease (RR/HR = 1.22, 95% CI [1.14, 1.30], P
Databáze:	Directory of Open Access Journals
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