Blood myxovirus resistance protein‐1 measurement in the diagnostic work‐up of suspected COVID‐19 infection in the emergency department

Autor: Kirby Tong‐Minh, Samantha vanHooijdonk, Marjan A. Versnel, Cornelia G. vanHelden‐Meeuwsen, Petrus Martin vanHagen, Eric C. M. vanGorp, Henrik Endeman, Yuri van derDoes, Virgil A. S. H. Dalm, Willem A Dik
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 10, Iss 4, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.609
Popis: Abstract Introduction Myxovirus resistance protein 1 (MxA) is a biomarker that is elevated in patients with viral infections. The goal of this study was to evaluate the diagnostic value of MxA in diagnosing COVID‐19 infections in the emergency department (ED) patients. Methods This was a single‐center prospective observational cohort study including patients with a suspected COVID‐19 infection. The primary outcome of this study was a confirmed COVID‐19 infection by RT‐PCR test. MxA was assessed using an enzyme immunoassay on whole blood and receiver operating chart and area under the curve (AUC) analysis was conducted. Sensitivity, specificity, negative predictive value, and positive predictive value of MxA on diagnosing COVID‐19 at the optimal cut‐off of MxA was determined. Results In 2021, 100 patients were included. Of these patients, 77 patients had COVID‐19 infection and 23 were non‐COVID‐19. Median MxA level was significantly higher (p
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje