Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas

Autor: Fuguo Wu, Jonathan E. Bard, Julien Kann, Donald Yergeau, Darshan Sapkota, Yichen Ge, Zihua Hu, Jie Wang, Tao Liu, Xiuqian Mu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-21704-4
Popis: Atoh7 is essential for retinal ganglion cell (RGC) genesis. Here the authors perform scRNAseq on embryonic mouse retina and conclude that Atoh7 defines a transitional state and that other factors also participate in establishing the RGC lineage.
Databáze: Directory of Open Access Journals