Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
| Autor: | Z. Razzaque, D. Shaw, M. Bock, L. Maskell, J. Pickard, D. Sirinathsinghji, J. Longmore |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | The Scientific World Journal, Vol 1, Pp 17-17 (2001) |
| Druh dokumentu: | article |
| ISSN: | 1537-744X |
| DOI: | 10.1100/tsw.2001.437 |
| Popis: | Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA). |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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