| Autor: |
Uğur Hodoğlugil, Sinan Tanyolaç, David W. Williamson, Yadong Huang, Robert W. Mahley |
| Jazyk: |
angličtina |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 47, Iss 1, Pp 144-153 (2006) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1194/jlr.M500343-JLR200 |
| Popis: |
The apolipoprotein A-V gene (APOA5) plays an important role in determining plasma triglyceride levels. We studied the effects of APOA5 polymorphisms on plasma triglyceride levels in Turks, a population with low levels of HDL cholesterol and a high prevalence of coronary artery disease. We found 15 polymorphisms, three of which were novel. Seven haplotype-tagging single nucleotide polymorphisms (SNPs) were chosen and genotyped in ∼3,000 subjects. The rare alleles of the −1464T>C, −1131T>C, S19W, and 1259T>C SNPs were significantly associated with increased triglyceride levels (19–86 mg/dl; P < 0.05) and had clear gene-dose effects. Haplotype analysis of the nine common APOA5 haplotypes revealed significant effects on triglyceride levels (P < 0.001). Detailed analysis of haplotypes clearly showed that the −1464T>C polymorphism had no effect by itself but was a marker for the −1131T>C, S19W, and 1259T>C polymorphisms. The −1131T>C and 1259T>C polymorphisms were in a strong but incomplete linkage disequilibrium and appeared to have independent effects. Thus, the APOA5 −1131T>C, S19W, and 1259T>C rare alleles were associated with significant increases in plasma triglyceride levels. At least one of these alleles was present in ∼40% of the Turks. Similar associations were observed for −1131T>C and S19W in white Americans living in San Francisco, California. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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