Lifestyle as well as metabolic syndrome and non-alcoholic fatty liver disease: an umbrella review of evidence from observational studies and randomized controlled trials

Autor:	Xiaojuan Peng, Juan Li, Hailiang Zhao, Junlong Lai, Junqin Lin, Shaohui Tang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Lifestyle Metabolic syndrome non-alcoholic fatty liver disease Umbrella review Meta-analyses Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	BMC Endocrine Disorders, Vol 22, Iss 1, Pp 1-16 (2022)
Druh dokumentu:	article
ISSN:	1472-6823
DOI:	10.1186/s12902-022-01015-5
Popis:	Abstract Background & Aims Recent epidemiological studies have indicated that NAFLD is pathologically associated with a sedentary lifestyle, unhealthy dietary habits and metabolic syndrome. An umbrella review of meta-analyses was performed to summarize the quality of evidence regarding the epidemiologic associations between lifestyle, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD) in regards to risk and treatment. Methods We searched PubMed, Web of Science and Embase Database from inception until June 1, 2021. Meta-analyses of observational studies and randomized controlled trials (RCTs) examining the associations of lifestyle as well as metabolic syndrome with NAFLD risk or treatment were screened. We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their P values, 95% prediction intervals, heterogeneity, and small-study effects. For meta-analyses of RCTs, outcomes with a random-effect P
Databáze:	Directory of Open Access Journals
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