| Autor: |
Hiroo Katsuya, Hideaki Nakamura, Aya Maeda, Keitaro Ishii, Toshiaki Nagaie, Haruhiko Sano, Haruna Sano, Hidekazu Itamura, Sho Okamoto, Toshihiko Ando, Toshiki Watanabe, Kaoru Uchimaru, Yorifumi Satou, Eisaburo Sueoka, Shinya Kimura |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
eJHaem, Vol 4, Iss 3, Pp 733-737 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2688-6146 |
| DOI: |
10.1002/jha2.725 |
| Popis: |
Abstract Viral cell‐free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus‐associated tumors. We investigated whether the amount of cfDNA of human T‐cell leukemia virus type 1 (HTLV‐1) correlates with disease state in adult T‐cell leukemia‐lymphoma (ATL). HTLV‐1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV‐1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV‐1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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