| Autor: |
J.Y. Yan, P.P. Chen, L.L. Jiang, H.L. Zhang, Q. Han, R.X. Chen, Q.J. Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Clinical and Experimental Obstetrics & Gynecology, Vol 47, Iss 4, Pp 565-570 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0390-6663 |
| DOI: |
10.31083/j.ceog.2020.04.5243 |
| Popis: |
Objective: This study aims to explore the role of hypoxia inducible factor-1α (HIF-1α) in morbidly adherent placenta (MAP). Materials and Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa, and 30 normal pregnant women as controls participated in the present study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of HIF-1α in the placenta. Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the HIF-1α protein levels in the placenta. Results: The mean expression of placental HIF-1α in the placenta increta and placenta previa groups was significantly higher than that in the normal placenta. The level of placental HIF-1α in the placenta increta was significantly higher than that in the placenta previa (p < 0.05). The level of placental HIF-1α had no obvious correlation with the accreta site and umbilical cord insertion. Conclusion: The morbidly of adherent placenta is closely correlated to adverse pregnancy outcomes during the perinatal period. Placental HIF-1α is associated with morbidly adherent placenta. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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